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Further, secondary changes due to bile duct obstruction may be seen including cholate stasis ( Figure 9 ), bile ductular proliferation, and periportal copper deposition

Research has indicated that dietary choices, particularly high-fat diets, significantly influence the gut microbiota, exacerbating DED symptoms through mechanisms such as decreased tear secretion, increased oxidative stress, and heightened apoptosis (Wu et al., 2020)

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Together with previous work showing that perturbations of the N-terminal loop or -SNAP/Sec17 membrane engagement compromise SNARE complex disassembly and membrane fusion dynamics 11,37,38 , these findings support the idea that the M105I mutation may impair membrane fusion not only by diminishing plasma membrane binding, but also by diverting -SNAP into non-productive, off-pathway membrane contacts that cannot support a properly assembled 20S complex

In a mouse model with heterozygous mutants of tuberous sclerosis complex 2 (TSC2), which is a cause of tuberous sclerosis manifesting with seizures, autism, and cognitive deficits [138], a global reduction of histone H3 acetylation was found in hippocampus tissues